Assay Detail
Functional
CHEMBL5355149
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tissue factor induced platelet activation in 76% human blood incubated for 15 mins by CD62 antibody based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Cell Type | Platelet |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of novel N-acylpyrazoles as potent and selective thrombin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.58 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198362 | RIVAROXABAN | 4.0 | 1 | 8.00 |
| CHEMBL502016 | — | — | 1 | 7.62 |
| CHEMBL48361 | DABIGATRAN | 3.0 | 1 | 7.54 |
| CHEMBL231779 | APIXABAN | 4.0 | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198362 | RIVAROXABAN | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL502016 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL48361 | DABIGATRAN | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL231779 | APIXABAN | EC50 | = | 70.0 | nM | 7.16 |