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Assay Detail

CHEMBL5355386

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HT-29 cells incubated for 24 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Autocuration

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Resveratrol derivatives: Synthesis and their biological activities.
Grau L, Soucek R, Pujol MD.
Eur J Med Chem (2023) 246 : 114962 -114962
PubMed 36463729 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.53 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5409579 1 5.00
CHEMBL3220147 1 4.92
CHEMBL5431521 1 4.85
CHEMBL296411 TRISMETHOXYRESVERATROL 1 4.80
CHEMBL5400584 1 4.72
CHEMBL5436858 1 4.64
CHEMBL5430375 1 4.25
CHEMBL5424856 1 4.25
CHEMBL512578 MORACIN M 1 4.14
CHEMBL5419610 1 4.11
CHEMBL165 RESVERATROL 3.0 1 4.11
CHEMBL5414592 1 -
CHEMBL5417839 1 -
CHEMBL5418811 1 -
CHEMBL5429092 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5409579 IC50 = 10000.0 nM 5.00
CHEMBL3220147 IC50 = 12000.0 nM 4.92
CHEMBL5431521 IC50 = 14000.0 nM 4.85
CHEMBL296411 TRISMETHOXYRESVERATROL IC50 = 16000.0 nM 4.80
CHEMBL5400584 IC50 = 19000.0 nM 4.72
CHEMBL5436858 IC50 = 23000.0 nM 4.64
CHEMBL5430375 IC50 = 56000.0 nM 4.25
CHEMBL5424856 IC50 = 56000.0 nM 4.25
CHEMBL512578 MORACIN M IC50 = 73000.0 nM 4.14
CHEMBL5419610 IC50 = 78000.0 nM 4.11
CHEMBL165 RESVERATROL IC50 = 78000.0 nM 4.11
CHEMBL5414592 IC50 = 134000.0 nM -
CHEMBL5417839 IC50 = 239000.0 nM -
CHEMBL5418811 IC50 = 211000.0 nM -
CHEMBL5429092 IC50 = 331000.0 nM -