Assay Detail
Toxicity
CHEMBL5355408
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against PBMC (unknown origin) cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter Glo luminescence based MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Not specified |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.14 | 4.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5404825 | — | — | 1 | 4.14 |
| CHEMBL5397580 | — | — | 1 | - |
| CHEMBL5411137 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5404825 | — | IC50 | = | 71800.0 | nM | 4.14 |
| CHEMBL5397580 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL5411137 | — | IC50 | > | 200000.0 | nM | - |