Assay Detail
Binding
CHEMBL5355887
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Inhibition of human recombinant HDAC1 using fluorogenic p53 (379-382 residues) (RHKK(Ac)AMC) as substrate
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.45 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5409409 | — | — | 1 | 7.20 |
| CHEMBL5429873 | — | — | 1 | 7.17 |
| CHEMBL5408688 | — | — | 1 | 7.11 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.11 |
| CHEMBL5400896 | — | — | 1 | 7.09 |
| CHEMBL4550522 | — | — | 1 | 7.01 |
| CHEMBL5396543 | — | — | 1 | 6.97 |
| CHEMBL5429446 | — | — | 1 | 6.89 |
| CHEMBL5412379 | — | — | 1 | 6.84 |
| CHEMBL5396691 | — | — | 1 | 6.82 |
| CHEMBL5417858 | — | — | 1 | 6.72 |
| CHEMBL5419832 | — | — | 1 | 6.70 |
| CHEMBL5414244 | — | — | 1 | 6.69 |
| CHEMBL5433683 | — | — | 1 | 6.49 |
| CHEMBL5399910 | — | — | 1 | 6.48 |
| CHEMBL5409567 | — | — | 1 | 6.45 |
| CHEMBL5401106 | — | — | 1 | 6.42 |
| CHEMBL5420814 | — | — | 1 | 6.30 |
| CHEMBL5411948 | — | — | 1 | 6.11 |
| CHEMBL5425559 | — | — | 1 | 6.00 |
| CHEMBL3426804 | — | — | 1 | 5.85 |
| CHEMBL5418060 | — | — | 1 | 5.83 |
| CHEMBL4521590 | — | — | 1 | 5.54 |
| CHEMBL4435005 | — | — | 1 | 5.52 |
| CHEMBL5426896 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5409409 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5429873 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL5408688 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL5400896 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4550522 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5396543 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL5429446 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL5412379 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL5396691 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL5417858 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL5419832 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL5414244 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL5433683 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL5399910 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL5409567 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL5401106 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL5420814 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL5411948 | — | IC50 | = | 783.0 | nM | 6.11 |
| CHEMBL5425559 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL3426804 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL5418060 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4521590 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL4435005 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5426896 | — | IC50 | = | 94000.0 | nM | 4.03 |