Assay Detail
Binding
CHEMBL5355890
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant HDAC6 using fluorogenic p53 (379-382 residues) (RHKK(Ac)AMC) as substrate
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.54 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.00 |
| CHEMBL5400896 | — | — | 1 | 8.00 |
| CHEMBL5408688 | — | — | 1 | 7.96 |
| CHEMBL3426804 | — | — | 1 | 7.96 |
| CHEMBL5429873 | — | — | 1 | 7.89 |
| CHEMBL4550522 | — | — | 1 | 7.82 |
| CHEMBL5411948 | — | — | 1 | 7.80 |
| CHEMBL5425559 | — | — | 1 | 7.39 |
| CHEMBL5418060 | — | — | 1 | 7.29 |
| CHEMBL4521590 | — | — | 1 | 7.24 |
| CHEMBL5401106 | — | — | 1 | 6.95 |
| CHEMBL5426896 | — | — | 1 | 6.91 |
| CHEMBL4435005 | — | — | 1 | 6.76 |
| CHEMBL5414244 | — | — | 1 | - |
| CHEMBL5409409 | — | — | 1 | - |
| CHEMBL5420814 | — | — | 1 | - |
| CHEMBL5419832 | — | — | 1 | - |
| CHEMBL5433683 | — | — | 1 | - |
| CHEMBL5399910 | — | — | 1 | - |
| CHEMBL5429446 | — | — | 1 | - |
| CHEMBL5412379 | — | — | 1 | - |
| CHEMBL5396543 | — | — | 1 | - |
| CHEMBL5396691 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5400896 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5408688 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3426804 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5429873 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4550522 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5411948 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5425559 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5418060 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4521590 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5401106 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL5426896 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL4435005 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL5414244 | — | IC50 | - | — | - | |
| CHEMBL5409409 | — | IC50 | - | — | - | |
| CHEMBL5420814 | — | IC50 | - | — | - | |
| CHEMBL5419832 | — | IC50 | - | — | - | |
| CHEMBL5433683 | — | IC50 | - | — | - | |
| CHEMBL5399910 | — | IC50 | - | — | - | |
| CHEMBL5429446 | — | IC50 | - | — | - | |
| CHEMBL5412379 | — | IC50 | - | — | - | |
| CHEMBL5396543 | — | IC50 | - | — | - | |
| CHEMBL5396691 | — | IC50 | - | — | - |