Assay Detail
Binding
CHEMBL5355897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant HDAC11 using fluorogenic class IIa (Bos-Lys(trifluoroacetyl)-AMC) as substrate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.62 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.00 |
| CHEMBL4550522 | — | — | 1 | 5.40 |
| CHEMBL3426804 | — | — | 1 | 4.99 |
| CHEMBL5409567 | — | — | 1 | 4.07 |
| CHEMBL5417858 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4550522 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL3426804 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL5409567 | — | IC50 | = | 85400.0 | nM | 4.07 |
| CHEMBL5417858 | — | IC50 | - | — | - |