Assay Detail
Functional
CHEMBL5355900
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Antiproliferative activity against human K562 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.27 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3426804 | — | — | 1 | 7.40 |
| CHEMBL4550522 | — | — | 1 | 7.30 |
| CHEMBL5401106 | — | — | 1 | 6.89 |
| CHEMBL5400896 | — | — | 1 | 6.75 |
| CHEMBL5409567 | — | — | 1 | 6.50 |
| CHEMBL5417858 | — | — | 1 | 6.43 |
| CHEMBL5411948 | — | — | 1 | 6.31 |
| CHEMBL5419832 | — | — | 1 | 6.27 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.27 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.24 |
| CHEMBL5429873 | — | — | 1 | 6.04 |
| CHEMBL5425559 | — | — | 1 | 5.98 |
| CHEMBL5414244 | — | — | 1 | 5.77 |
| CHEMBL5418060 | — | — | 1 | 5.75 |
| CHEMBL5420814 | — | — | 1 | 5.73 |
| CHEMBL5396691 | — | — | 1 | 5.54 |
| CHEMBL5409409 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3426804 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4550522 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5401106 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5400896 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5409567 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5417858 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5411948 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5419832 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5429873 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5425559 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL5414244 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5418060 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL5420814 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL5396691 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL5409409 | — | IC50 | = | 3140.0 | nM | 5.50 |