Assay Detail
Functional
CHEMBL5355945
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Antiproliferative activity against human KARPAS-299 cells incubated for 48 hrs
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KARPAS-299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.60 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4550522 | — | — | 1 | 6.40 |
| CHEMBL272980 | MOCETINOSTAT | 2.0 | 1 | 5.38 |
| CHEMBL5417858 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4550522 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL272980 | MOCETINOSTAT | IC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL5417858 | — | IC50 | = | 9270.0 | nM | 5.03 |