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Assay Detail

CHEMBL5355949

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Prenylated flavonoids with significant anti-hepatoma activity from Daphne giraldii and effects on Fibroblast Growth Factor Receptor 1 (FGFR1).
Liu Y, Gao P, Liang X, Zhang Y, Yu X, Xue X, Kockaya L, Pandey P, Doerksen RJ, Wang X, Yao G, Chu W, Chen X, Song S, Hamann MT, Li L.
Eur J Med Chem (2023) 247 : 115006 -115006
PubMed 36549116 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 4.52 5.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1336 SORAFENIB 4.0 1 5.19
CHEMBL5403460 1 4.91
CHEMBL5402916 1 4.87
CHEMBL5418580 1 4.57
CHEMBL5431484 1 4.52
CHEMBL464007 BROUSSOFLAVONOL F 1 4.51
CHEMBL5440596 1 4.51
CHEMBL5397900 1 4.49
CHEMBL5424491 1 4.43
CHEMBL5417448 1 4.41
CHEMBL5421433 1 4.40
CHEMBL5433902 1 4.37
CHEMBL4466409 1 4.36
CHEMBL457679 ISOLICOFLAVONOL 1 4.35
CHEMBL5435732 1 4.32
CHEMBL5436865 1 4.31
CHEMBL3810225 1 4.30
CHEMBL5421934 1 -
CHEMBL5413733 1 -
CHEMBL5421478 1 -
CHEMBL5395968 1 -
CHEMBL5426293 1 -
CHEMBL5430013 1 -
CHEMBL5415194 1 -
CHEMBL5417321 1 -
CHEMBL5395749 1 -
CHEMBL5423394 1 -
CHEMBL5429121 1 -
CHEMBL5399081 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1336 SORAFENIB IC50 = 6422.0 nM 5.19
CHEMBL5403460 IC50 = 12320.0 nM 4.91
CHEMBL5402916 IC50 = 13590.0 nM 4.87
CHEMBL5418580 IC50 = 26950.0 nM 4.57
CHEMBL5431484 IC50 = 30380.0 nM 4.52
CHEMBL464007 BROUSSOFLAVONOL F IC50 = 30790.0 nM 4.51
CHEMBL5440596 IC50 = 30720.0 nM 4.51
CHEMBL5397900 IC50 = 32610.0 nM 4.49
CHEMBL5424491 IC50 = 36770.0 nM 4.43
CHEMBL5417448 IC50 = 39120.0 nM 4.41
CHEMBL5421433 IC50 = 39660.0 nM 4.40
CHEMBL5433902 IC50 = 42240.0 nM 4.37
CHEMBL4466409 IC50 = 43270.0 nM 4.36
CHEMBL457679 ISOLICOFLAVONOL IC50 = 44700.0 nM 4.35
CHEMBL5435732 IC50 = 47370.0 nM 4.32
CHEMBL5436865 IC50 = 49060.0 nM 4.31
CHEMBL3810225 IC50 = 50510.0 nM 4.30
CHEMBL5421934 IC50 > 50000.0 nM -
CHEMBL5413733 IC50 > 50000.0 nM -
CHEMBL5421478 IC50 > 50000.0 nM -
CHEMBL5395968 IC50 > 50000.0 nM -
CHEMBL5426293 IC50 > 50000.0 nM -
CHEMBL5430013 IC50 > 50000.0 nM -
CHEMBL5415194 IC50 > 50000.0 nM -
CHEMBL5417321 IC50 > 50000.0 nM -
CHEMBL5395749 IC50 > 50000.0 nM -
CHEMBL5423394 IC50 > 50000.0 nM -
CHEMBL5429121 IC50 > 50000.0 nM -
CHEMBL5399081 IC50 > 50000.0 nM -