Assay Detail
Binding
CHEMBL5355960
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Binding affinity to Pseudomonas aeruginosa LecA assessed as dissociation constant by isothermal titration calorimetry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
PA-I galactophilic lectin (CHEMBL3351196) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
Discovery of potent 1,1-diarylthiogalactoside glycomimetic inhibitors of Pseudomonas aeruginosa LecA with antibiofilm properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 5.24 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397352 | — | — | 1 | 7.55 |
| CHEMBL5407860 | — | — | 1 | 5.27 |
| CHEMBL3590184 | — | — | 1 | 5.20 |
| CHEMBL157265 | — | — | 1 | 4.85 |
| CHEMBL1233651 | — | — | 1 | 4.49 |
| CHEMBL300520 | b-D-GALACTOSE | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397352 | — | Kd | = | 28.0 | nM | 7.55 |
| CHEMBL5407860 | — | Kd | = | 5400.0 | nM | 5.27 |
| CHEMBL3590184 | — | Kd | = | 6300.0 | nM | 5.20 |
| CHEMBL157265 | — | Kd | = | 14100.0 | nM | 4.85 |
| CHEMBL1233651 | — | Kd | = | 32400.0 | nM | 4.49 |
| CHEMBL300520 | b-D-GALACTOSE | Kd | = | 87500.0 | nM | 4.06 |