Assay Detail
Functional
CHEMBL5356135
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Antiproliferative activity against human Daudi cells assessed as reduction in cell viability incubated for 2 days by CCK8 assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Daudi |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel quinazolinone derivatives as CRBN E3 ligase modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 6.92 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436848 | — | — | 1 | 7.89 |
| CHEMBL5436450 | — | — | 1 | 7.36 |
| CHEMBL5427410 | — | — | 1 | 7.28 |
| CHEMBL5433023 | — | — | 1 | 7.23 |
| CHEMBL5398430 | — | — | 1 | 6.98 |
| CHEMBL5431516 | — | — | 1 | 6.88 |
| CHEMBL5436648 | — | — | 1 | 6.84 |
| CHEMBL5437124 | — | — | 1 | 6.77 |
| CHEMBL3989934 | AVADOMIDE | 2.0 | 1 | 6.74 |
| CHEMBL5439534 | — | — | 1 | 6.64 |
| CHEMBL5398585 | — | — | 1 | 6.38 |
| CHEMBL5415973 | — | — | 1 | 6.07 |
| CHEMBL5414899 | — | — | 1 | - |
| CHEMBL5431858 | — | — | 1 | - |
| CHEMBL5429814 | — | — | 1 | - |
| CHEMBL5409711 | — | — | 1 | - |
| CHEMBL5415124 | — | — | 1 | - |
| CHEMBL5430601 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436848 | — | EC50 | = | 12.89 | nM | 7.89 |
| CHEMBL5436450 | — | EC50 | = | 43.97 | nM | 7.36 |
| CHEMBL5427410 | — | EC50 | = | 52.51 | nM | 7.28 |
| CHEMBL5433023 | — | EC50 | = | 59.11 | nM | 7.23 |
| CHEMBL5398430 | — | EC50 | = | 105.28 | nM | 6.98 |
| CHEMBL5431516 | — | EC50 | = | 130.85 | nM | 6.88 |
| CHEMBL5436648 | — | EC50 | = | 144.8 | nM | 6.84 |
| CHEMBL5437124 | — | EC50 | = | 170.25 | nM | 6.77 |
| CHEMBL3989934 | AVADOMIDE | EC50 | = | 182.3 | nM | 6.74 |
| CHEMBL5439534 | — | EC50 | = | 226.4 | nM | 6.64 |
| CHEMBL5398585 | — | EC50 | = | 421.9 | nM | 6.38 |
| CHEMBL5415973 | — | EC50 | = | 848.6 | nM | 6.07 |
| CHEMBL5414899 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5431858 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5429814 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5409711 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5415124 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL5430601 | — | EC50 | > | 1000.0 | nM | - |