Assay Detail
Binding
CHEMBL5356175
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Inhibition of wild type HIV-1 reverse transcriptase assessed as assessed as inhibition of biotin deoxyuridine triphosphate incorporation into protein
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Development of novel S-N<sub>3</sub>-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.76 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.80 |
| CHEMBL5405590 | — | — | 1 | 7.10 |
| CHEMBL5425978 | — | — | 1 | 7.00 |
| CHEMBL5411806 | — | — | 1 | 6.77 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.05 |
| CHEMBL374286 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5405590 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5425978 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5411806 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL374286 | — | IC50 | = | 1510.0 | nM | 5.82 |