Assay Detail
Binding
CHEMBL5356231
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR (unknown origin) using ULight-4E-BP1 (Thr37/46) as peptide substrate incubated for 30 mins in presence of ATP by LANCE Ultra assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b]pyridazine derivatives as potent PI3K/mTOR dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.85 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5395998 | — | — | 1 | 8.51 |
| CHEMBL4440406 | — | — | 1 | 7.68 |
| CHEMBL3218576 | COPANLISIB | 4.0 | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5395998 | — | IC50 | = | 3.12 | nM | 8.51 |
| CHEMBL4440406 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3218576 | COPANLISIB | IC50 | = | 45.0 | nM | 7.35 |