Assay Detail
Toxicity
CHEMBL5356320
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Antiproliferative against HLF1 cells measured after 48 hrs by CCK8 assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HFL1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dual inhibitors of ASK1 and PDK1 kinases: Design, synthesis, molecular docking and mechanism studies of N-benzyl pyridine-2-one containing derivatives as anti-fibrotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.57 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419388 | — | — | 1 | 5.10 |
| CHEMBL5400071 | — | — | 1 | 5.04 |
| CHEMBL5426009 | — | — | 1 | 4.97 |
| CHEMBL5424950 | — | — | 1 | 4.82 |
| CHEMBL5432766 | — | — | 1 | 4.75 |
| CHEMBL5405312 | — | — | 1 | 4.73 |
| CHEMBL5415758 | — | — | 1 | 4.53 |
| CHEMBL5399125 | — | — | 1 | 4.20 |
| CHEMBL1234429 | — | — | 1 | 4.19 |
| CHEMBL5435837 | — | — | 1 | 4.19 |
| CHEMBL5394085 | — | — | 1 | 4.17 |
| CHEMBL4783726 | — | — | 1 | 4.17 |
| CHEMBL5407513 | — | — | 1 | - |
| CHEMBL5417583 | — | — | 1 | - |
| CHEMBL5439242 | — | — | 1 | - |
| CHEMBL5417367 | — | — | 1 | - |
| CHEMBL5395030 | — | — | 1 | - |
| CHEMBL5424839 | — | — | 1 | - |
| CHEMBL5412415 | — | — | 1 | - |
| CHEMBL5421044 | — | — | 1 | - |
| CHEMBL5404747 | — | — | 1 | - |
| CHEMBL5401525 | — | — | 1 | - |
| CHEMBL5440185 | — | — | 1 | - |
| CHEMBL5414169 | — | — | 1 | - |
| CHEMBL5418366 | — | — | 1 | - |
| CHEMBL5437066 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419388 | — | IC50 | = | 7990.0 | nM | 5.10 |
| CHEMBL5400071 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL5426009 | — | IC50 | = | 10720.0 | nM | 4.97 |
| CHEMBL5424950 | — | IC50 | = | 15160.0 | nM | 4.82 |
| CHEMBL5432766 | — | IC50 | = | 17860.0 | nM | 4.75 |
| CHEMBL5405312 | — | IC50 | = | 18650.0 | nM | 4.73 |
| CHEMBL5415758 | — | IC50 | = | 29210.0 | nM | 4.53 |
| CHEMBL5399125 | — | IC50 | = | 62480.0 | nM | 4.20 |
| CHEMBL1234429 | — | IC50 | = | 64790.0 | nM | 4.19 |
| CHEMBL5435837 | — | IC50 | = | 64160.0 | nM | 4.19 |
| CHEMBL5394085 | — | IC50 | = | 68280.0 | nM | 4.17 |
| CHEMBL4783726 | — | IC50 | = | 67930.0 | nM | 4.17 |
| CHEMBL5407513 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5417583 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5439242 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5417367 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5395030 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5424839 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5412415 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5421044 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5404747 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5401525 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5440185 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5414169 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5418366 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL5437066 | — | IC50 | > | 80000.0 | nM | - |