Assay Detail
Binding
CHEMBL5356844
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Inhibition of HDAC1 in human HeLa nuclear extract
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Zinc-Binding Group Effect: Lessons from Non-Hydroxamic Acid Vorinostat Analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.57 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.29 |
| CHEMBL325676 | — | — | 1 | 7.24 |
| CHEMBL113537 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL325676 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL113537 | — | IC50 | = | 6700.0 | nM | 5.17 |