Assay Detail
Binding
CHEMBL5357185
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of eIF4E phosphorylation in human HeLa cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Eukaryotic translation initiation factor 4E (CHEMBL4848) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Medicinal chemistry approaches to target the MNK-eIF4E axis in cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.58 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4587832 | — | — | 1 | 6.70 |
| CHEMBL3806189 | — | — | 1 | 6.55 |
| CHEMBL4211649 | TINODASERTIB | 2.0 | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4587832 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3806189 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4211649 | TINODASERTIB | IC50 | = | 321.0 | nM | 6.49 |