Assay Detail
Functional
CHEMBL5357337
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against PYR-resistant Plasmodium falciparum V1/S encoding QM DHFR infected in human erythrocytes assessed as inhibition of parasite growth by [3H]-hypoxanthine incorporation assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of rigid biphenyl <i>Plasmodium falciparum</i> DHFR inhibitors using a fragment linking strategy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.02 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3040038 | — | — | 1 | 7.25 |
| CHEMBL5417784 | — | — | 1 | 4.53 |
| CHEMBL5406769 | — | — | 1 | 4.46 |
| CHEMBL5397904 | — | — | 1 | 4.46 |
| CHEMBL5415214 | — | — | 1 | 4.40 |
| CHEMBL5440218 | — | — | 1 | - |
| CHEMBL5404134 | — | — | 1 | - |
| CHEMBL5421199 | — | — | 1 | - |
| CHEMBL5432011 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3040038 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5417784 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL5406769 | — | IC50 | = | 34500.0 | nM | 4.46 |
| CHEMBL5397904 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL5415214 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL5440218 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5404134 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5421199 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5432011 | — | IC50 | > | 50000.0 | nM | - |