Assay Detail
Binding
CHEMBL5357352
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Inhibition of FLT3 D835Y mutant (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dual FLT3/haspin kinase inhibitor based on 3<i>H</i>-pyrazolo[4,3-<i>f</i>]quinoline scaffold with activities against acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 10.18 | 10.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5440655 | — | — | 1 | 10.62 |
| CHEMBL3301622 | GILTERITINIB | 4.0 | 1 | 9.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5440655 | — | IC50 | = | 0.024 | nM | 10.62 |
| CHEMBL3301622 | GILTERITINIB | IC50 | = | 0.187 | nM | 9.73 |