Assay Detail
Binding
CHEMBL5357372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged recombinant human CDK12 (696 to 1082 residues) expressed in Insect cell in presence of ATP by high ATP assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Insect cell |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Research progress of anticancer drugs targeting CDK12.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.88 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414905 | — | — | 1 | 7.33 |
| CHEMBL4649135 | — | — | 1 | 6.99 |
| CHEMBL5188909 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414905 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4649135 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL5188909 | — | IC50 | = | 491.0 | nM | 6.31 |