Assay Detail

CHEMBL5357429

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of ERK phosphorylation in human A-431 cells at 1 to 10 uM incubated for 24 hrs by Western blot analysis

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Cell Type	A-431
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

MEK inhibitors in cancer treatment: structural insights, regulation, recent advances and future perspectives.

Ram T, Singh AK, Kumar A, Singh H, Pathak P, Grishina M, Khalilullah H, Jaremko M, Jaremko M, Emwas AH, Verma A, Kumar P.
RSC Med Chem (2023) 14 : 1837 -1857
PubMed 37859720 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.72	9.72

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1615025	TAK-733	2.0	1	9.72

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1615025	TAK-733	IC50	=	0.19	nM	9.72