Assay Detail
Binding
CHEMBL5357582
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of XO (unknown origin) using xanthine as substrate assessed as decrease in uric acid level by spectrophotometric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Past, present and future of xanthine oxidase inhibitors: design strategies, structural and pharmacological insights, patents and clinical trials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.40 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456610 | — | — | 1 | 7.40 |
| CHEMBL5421228 | — | — | 1 | 5.65 |
| CHEMBL5394667 | — | — | 1 | 5.39 |
| CHEMBL5428048 | — | — | 1 | 5.17 |
| CHEMBL5432623 | — | — | 1 | 4.43 |
| CHEMBL5395909 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456610 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5421228 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL5394667 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL5428048 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5432623 | — | IC50 | = | 36880.0 | nM | 4.43 |
| CHEMBL5395909 | — | IC50 | = | 45450.0 | nM | 4.34 |