Assay Detail
Binding
CHEMBL5358039
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human NAMPT preincubated for 5 mins followed by NAM addition measured for 15 mins by fluorescence based assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nicotinamide phosphoribosyltransferase (CHEMBL1744525) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Dual Function Agents That Exhibit Anticancer Activity via Catastrophic Nicotinamide Adenine Dinucleotide Depletion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.02 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 9.82 |
| CHEMBL5429026 | — | — | 1 | 9.82 |
| CHEMBL5437893 | — | — | 1 | 9.80 |
| CHEMBL5439032 | — | — | 1 | 8.96 |
| CHEMBL5413966 | — | — | 1 | 8.89 |
| CHEMBL5416477 | — | — | 1 | 8.41 |
| CHEMBL5435058 | — | — | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL5429026 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL5437893 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL5439032 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL5413966 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5416477 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL5435058 | — | IC50 | = | 37.5 | nM | 7.43 |