Assay Detail
Functional
CHEMBL5358044
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Antitumor activity against human LN-18 cells assessed as inhibition of cell viability incubated for 72 hrs by SRB assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LN-18 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Dual Function Agents That Exhibit Anticancer Activity via Catastrophic Nicotinamide Adenine Dinucleotide Depletion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.04 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5429026 | — | — | 1 | 9.15 |
| CHEMBL5437893 | — | — | 1 | 7.50 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 7.47 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5429026 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL5437893 | — | IC50 | = | 31.3 | nM | 7.50 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 33.6 | nM | 7.47 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | > | 1000.0 | nM | - |