Assay Detail
Functional
CHEMBL5358045
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Antitumor activity against human Hepa1-6 cells assessed as inhibition of cell viability incubated for 72 hrs by SRB assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hepa1-6 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Dual Function Agents That Exhibit Anticancer Activity via Catastrophic Nicotinamide Adenine Dinucleotide Depletion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.68 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5429026 | — | — | 1 | 8.29 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 7.47 |
| CHEMBL5437893 | — | — | 1 | 7.29 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5429026 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 33.6 | nM | 7.47 |
| CHEMBL5437893 | — | IC50 | = | 51.6 | nM | 7.29 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | > | 1000.0 | nM | - |