Assay Detail
Functional
CHEMBL5358762
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Research status of indole-modified natural products.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.83 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3597212 | — | — | 1 | 10.00 |
| CHEMBL5274508 | — | — | 1 | 9.20 |
| CHEMBL3597223 | — | — | 1 | 7.28 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.09 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3597212 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5274508 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL3597223 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2600.0 | nM | 5.58 |