Assay Detail
Binding
CHEMBL5358932
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Inhibition of Staphylococcus aureus DNA gyrase subunit B ATPase activity using relaxed pNO1 plasmid as substrate incubated for 30 mins by microplate reader analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological and molecular modelling for 1,3,4-thiadiazole sulfonyl thioureas: bacterial and fungal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.79 | 5.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 5.93 |
| CHEMBL5422204 | — | — | 1 | 5.91 |
| CHEMBL5419490 | — | — | 1 | 5.81 |
| CHEMBL5427814 | — | — | 1 | 5.79 |
| CHEMBL5407144 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL5422204 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5419490 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL5427814 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL5407144 | — | IC50 | = | 3170.0 | nM | 5.50 |