Assay Detail
Binding
CHEMBL5358933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus DNA topoisomerase 4 subunit B ATPase activity using relaxed pNO1 plasmid as substrate incubated for 30 mins by microplate reader analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA topoisomerase 4 subunit B (CHEMBL2150841) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Synthesis, biological and molecular modelling for 1,3,4-thiadiazole sulfonyl thioureas: bacterial and fungal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.27 | 4.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 4.62 |
| CHEMBL5422204 | — | — | 1 | 4.27 |
| CHEMBL5427814 | — | — | 1 | 4.18 |
| CHEMBL5419490 | — | — | 1 | 4.17 |
| CHEMBL5407144 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 24110.0 | nM | 4.62 |
| CHEMBL5422204 | — | IC50 | = | 53780.0 | nM | 4.27 |
| CHEMBL5427814 | — | IC50 | = | 66720.0 | nM | 4.18 |
| CHEMBL5419490 | — | IC50 | = | 67620.0 | nM | 4.17 |
| CHEMBL5407144 | — | IC50 | = | 78120.0 | nM | 4.11 |