Assay Detail
Functional
CHEMBL5359113
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-osteoclastogensis in C57BL/6 mouse bone marrow monocytes assessed as inhibition of RANKL/M-CSF induced osteoclastogenesis at 10 uM incubated for 5 days
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Monocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pestanoid A, a Rearranged Pimarane Diterpenoid Osteoclastogenesis Inhibitor from a Marine Mesophotic Zone Chalinidae Sponge-Associated Fungus, <i>Pestalotiopsis</i> sp. NBUF145.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.45 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5397856 | — | — | 1 | 5.52 |
| CHEMBL5440345 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5397856 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5440345 | — | IC50 | = | 4200.0 | nM | 5.38 |