Assay Detail
Functional
CHEMBL5359174
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Partial agonist activity at 5-HT2CR (unknown origin) expressed in HEK293T cells assessed as increase in calcium flux measured for 3 mins by FLIPR assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Spiro[chromene-2,4'-piperidine]s as Potent, Selective, and G<sub>q</sub>-Biased 5-HT<sub>2C</sub> Receptor Partial Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.51 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469423 | (-)-ASIMILOBINE | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469423 | (-)-ASIMILOBINE | EC50 | = | 308.0 | nM | 6.51 |