Assay Detail
Binding
CHEMBL5359178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 20 secs for 3 mins by Ellman's method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, Antiacetylcholinesterase Activity, and Molecular Dynamics Simulation of Aporphine-benzylpyridinium Conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.17 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 7.30 |
| CHEMBL5435446 | — | — | 1 | 7.22 |
| CHEMBL5411326 | — | — | 1 | 6.92 |
| CHEMBL5397094 | — | — | 1 | 6.75 |
| CHEMBL5420759 | — | — | 1 | 6.46 |
| CHEMBL5401023 | — | — | 1 | 6.43 |
| CHEMBL5413249 | — | — | 1 | 6.39 |
| CHEMBL5433803 | — | — | 1 | 6.35 |
| CHEMBL5418957 | — | — | 1 | 6.18 |
| CHEMBL5421487 | — | — | 1 | 6.12 |
| CHEMBL5405227 | — | — | 1 | 6.10 |
| CHEMBL5423996 | — | — | 1 | 5.79 |
| CHEMBL5396980 | — | — | 1 | 5.67 |
| CHEMBL5415333 | — | — | 1 | 5.56 |
| CHEMBL5397579 | — | — | 1 | 5.53 |
| CHEMBL5401594 | — | — | 1 | 5.15 |
| CHEMBL5435159 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5435446 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5411326 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5397094 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5420759 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5401023 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5413249 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5433803 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5418957 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5421487 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5405227 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL5423996 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL5396980 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL5415333 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL5397579 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL5401594 | — | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL5435159 | — | IC50 | = | 12160.0 | nM | 4.92 |