Assay Detail
Binding
CHEMBL5359184
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Binding affinity to electric eel AChE assessed as inhibition constant by Lineweaver-Burk plot analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, Antiacetylcholinesterase Activity, and Molecular Dynamics Simulation of Aporphine-benzylpyridinium Conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.28 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | 4.0 | 1 | 7.40 |
| CHEMBL5411326 | — | — | 1 | 6.77 |
| CHEMBL5435446 | — | — | 1 | 6.66 |
| CHEMBL5401023 | — | — | 1 | 6.57 |
| CHEMBL5397579 | — | — | 1 | 5.78 |
| CHEMBL5401594 | — | — | 1 | 5.59 |
| CHEMBL5435159 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1678 | DONEPEZIL HYDROCHLORIDE | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL5411326 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL5435446 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL5401023 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL5397579 | — | Ki | = | 1650.0 | nM | 5.78 |
| CHEMBL5401594 | — | Ki | = | 2570.0 | nM | 5.59 |
| CHEMBL5435159 | — | Ki | = | 6870.0 | nM | 5.16 |