Assay Detail
Binding
CHEMBL5359191
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of autophagic protein LC3-B mediated PDEdelta degradation in human MIA PaCa-2 cells harboring KRAS mutant measured after 24 hrs by Western blot analysis
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of Novel PDEδ Autophagic Degraders: A Case Study of Autophagy-Tethering Compound (ATTEC).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 2 | - | - |
| EC50 | 2 | 5.26 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5439010 | — | — | 2 | 5.77 |
| CHEMBL5431289 | — | — | 2 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5439010 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5431289 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5431289 | — | Activity | - | — | - | |
| CHEMBL5439010 | — | Activity | - | — | - |