Assay Detail
Functional
CHEMBL5359450
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Cytotoxicity against human MDAMB-435 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Acetogenins from the Stem of <i>Uvaria rufa</i> and Their Cytotoxic Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.67 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.59 |
| CHEMBL1933125 | UVARIGRANDIN A | — | 1 | 5.39 |
| CHEMBL62800 | ISODESAACETYLUVARICIN | — | 1 | 5.39 |
| CHEMBL5426008 | — | — | 1 | 5.36 |
| CHEMBL5399730 | — | — | 1 | 5.36 |
| CHEMBL5434987 | — | — | 1 | 5.35 |
| CHEMBL5431384 | — | — | 1 | 5.34 |
| CHEMBL41177 | SQUAMOCIN | — | 1 | 5.34 |
| CHEMBL5410230 | — | — | 1 | 5.34 |
| CHEMBL145449 | BULLANIN | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1933125 | UVARIGRANDIN A | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL62800 | ISODESAACETYLUVARICIN | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5426008 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5399730 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5434987 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5431384 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL41177 | SQUAMOCIN | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5410230 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL145449 | BULLANIN | IC50 | = | 5300.0 | nM | 5.28 |