Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5359452

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human 22Rv1 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CWR22R
Confidence 1 — Organism
Curated By Autocuration

Target

CWR22R (CHEMBL612657)
Type CELL-LINE
Organism Homo sapiens

Publication

Acetogenins from the Stem of <i>Uvaria rufa</i> and Their Cytotoxic Activity.
Gurgul A, Khin M, Souliya O, Sydara K, Burdette JE, Johnson JJ, Che CT.
J Nat Prod (2024) 87 : 207 -216
PubMed 38237151 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.38 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL378544 VINBLASTINE SULFATE 4.0 1 9.00
CHEMBL44657 ETOPOSIDE 4.0 1 5.64
CHEMBL5399730 1 5.26
CHEMBL5434987 1 5.25
CHEMBL41177 SQUAMOCIN 1 5.19
CHEMBL1933125 UVARIGRANDIN A 1 5.16
CHEMBL62800 ISODESAACETYLUVARICIN 1 5.11
CHEMBL5426008 1 5.09
CHEMBL5431384 1 5.08
CHEMBL5405302 1 4.90
CHEMBL145449 BULLANIN 1 4.78
CHEMBL5410230 1 4.76
CHEMBL5434055 1 4.74

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL378544 VINBLASTINE SULFATE IC50 = 1.0 nM 9.00
CHEMBL44657 ETOPOSIDE IC50 = 2300.0 nM 5.64
CHEMBL5399730 IC50 = 5500.0 nM 5.26
CHEMBL5434987 IC50 = 5600.0 nM 5.25
CHEMBL41177 SQUAMOCIN IC50 = 6400.0 nM 5.19
CHEMBL1933125 UVARIGRANDIN A IC50 = 7000.0 nM 5.16
CHEMBL62800 ISODESAACETYLUVARICIN IC50 = 7800.0 nM 5.11
CHEMBL5426008 IC50 = 8200.0 nM 5.09
CHEMBL5431384 IC50 = 8300.0 nM 5.08
CHEMBL5405302 IC50 = 12500.0 nM 4.90
CHEMBL145449 BULLANIN IC50 = 16500.0 nM 4.78
CHEMBL5410230 IC50 = 17500.0 nM 4.76
CHEMBL5434055 IC50 = 18300.0 nM 4.74