Assay Detail
Binding
CHEMBL5359744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ALDH1A1 using propionaldehyde as substrate preincubated with enzyme for 15 mins followed by substrate addition in presence of NAD+ and measured for 5 mins by spectrophotometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Scaffold hopping based designing of selective ALDH1A1 inhibitors to overcome cyclophosphamide resistance: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.93 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5396348 | — | — | 1 | 6.50 |
| CHEMBL5403165 | — | — | 1 | 6.26 |
| CHEMBL4215649 | — | — | 1 | 6.05 |
| CHEMBL1453086 | — | — | 1 | 5.79 |
| CHEMBL1922082 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5396348 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5403165 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4215649 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL1453086 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL1922082 | — | IC50 | = | 8670.0 | nM | 5.06 |