Assay Detail
Toxicity
CHEMBL5359784
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Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth incubated for 72 hrs by WST-1 assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and migrastatic activity of cytochalasin analogues lacking a macrocyclic moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.77 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411729 | CYTOCHALASIN B | — | 1 | 6.57 |
| CHEMBL260287 | CYTOCHALASIN D | — | 1 | 5.63 |
| CHEMBL5412367 | — | — | 1 | 4.68 |
| CHEMBL5429339 | — | — | 1 | 4.67 |
| CHEMBL5412085 | — | — | 1 | 4.65 |
| CHEMBL5433011 | — | — | 1 | 4.54 |
| CHEMBL5425649 | — | — | 1 | 4.52 |
| CHEMBL5400427 | — | — | 1 | 4.51 |
| CHEMBL5438447 | — | — | 1 | 4.50 |
| CHEMBL5432823 | — | — | 1 | 4.47 |
| CHEMBL5410157 | — | — | 1 | 4.46 |
| CHEMBL5431385 | — | — | 1 | 4.46 |
| CHEMBL5409980 | — | — | 1 | 4.39 |
| CHEMBL5414176 | — | — | 1 | - |
| CHEMBL5398254 | — | — | 1 | - |
| CHEMBL5423225 | — | — | 1 | - |
| CHEMBL5413982 | — | — | 1 | - |
| CHEMBL5405728 | — | — | 1 | - |
| CHEMBL5396519 | — | — | 1 | - |
| CHEMBL5405447 | — | — | 1 | - |
| CHEMBL5434705 | — | — | 1 | - |
| CHEMBL5401518 | — | — | 1 | - |
| CHEMBL5401563 | — | — | 1 | - |
| CHEMBL5435236 | — | — | 1 | - |
| CHEMBL5431222 | — | — | 1 | - |
| CHEMBL5418483 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411729 | CYTOCHALASIN B | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL260287 | CYTOCHALASIN D | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL5412367 | — | IC50 | = | 20890.0 | nM | 4.68 |
| CHEMBL5429339 | — | IC50 | = | 21540.0 | nM | 4.67 |
| CHEMBL5412085 | — | IC50 | = | 22170.0 | nM | 4.65 |
| CHEMBL5433011 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL5425649 | — | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL5400427 | — | IC50 | = | 31190.0 | nM | 4.51 |
| CHEMBL5438447 | — | IC50 | = | 31930.0 | nM | 4.50 |
| CHEMBL5432823 | — | IC50 | = | 33530.0 | nM | 4.47 |
| CHEMBL5410157 | — | IC50 | = | 34460.0 | nM | 4.46 |
| CHEMBL5431385 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL5409980 | — | IC50 | = | 40540.0 | nM | 4.39 |
| CHEMBL5414176 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5398254 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5423225 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5413982 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5405728 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5396519 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5405447 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5434705 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5401518 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5401563 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5435236 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5431222 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5418483 | — | IC50 | > | 50000.0 | nM | - |