Assay Detail
Binding
CHEMBL5359917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus CrtM
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
4,4'-diapophytoene synthase (CHEMBL5440) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
The development of thymol-isatin hybrids as broad-spectrum antibacterial agents with potent anti-MRSA activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.40 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87292 | — | — | 1 | 9.70 |
| CHEMBL351151 | — | — | 1 | 8.82 |
| CHEMBL513790 | — | — | 1 | 8.22 |
| CHEMBL5402466 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87292 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL351151 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL513790 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL5402466 | — | Ki | = | 135.0 | nM | 6.87 |