Assay Detail
Functional
CHEMBL5360018
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human OX2R expressed in CHO/dhfr- cells assessed as inhibition of orexin B-induced intracellular Ca2+ mobilization preincubated for 25 mins followed by orexin B addition by FLIPR assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO/dhfr- |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure-activity-relationship, and sleep-promoting properties in rats.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.10 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2385132 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2385132 | — | IC50 | = | 8.0 | nM | 8.10 |