Assay Detail
Binding
CHEMBL5360233
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Agonist activity at human TLR7 in HEK-Blue hTLR7 cells incubated for 18 hrs by QUANTI-Blue reagent based SEAP reporter assay
29
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-Blue hTLR7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.87 | 8.70 |
| IC50 | 10 | 6.98 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5433689 | — | — | 1 | 8.85 |
| CHEMBL5429027 | — | — | 1 | 8.70 |
| CHEMBL5419663 | — | — | 1 | 7.92 |
| CHEMBL5407132 | — | — | 1 | 7.82 |
| CHEMBL5431826 | — | — | 1 | 7.64 |
| CHEMBL5418486 | — | — | 1 | 7.62 |
| CHEMBL5434111 | — | — | 1 | 7.36 |
| CHEMBL5399638 | — | — | 1 | 7.36 |
| CHEMBL5416423 | — | — | 1 | 7.27 |
| CHEMBL5439307 | — | — | 1 | 7.10 |
| CHEMBL5409254 | — | — | 1 | 7.01 |
| CHEMBL5440967 | — | — | 1 | 6.85 |
| CHEMBL5401895 | — | — | 1 | 6.80 |
| CHEMBL5437820 | — | — | 1 | 6.71 |
| CHEMBL5425931 | — | — | 1 | 6.69 |
| CHEMBL5435487 | — | — | 1 | 6.53 |
| CHEMBL5398234 | — | — | 1 | 6.52 |
| CHEMBL5397470 | — | — | 1 | 6.49 |
| CHEMBL5397705 | — | — | 1 | 6.48 |
| CHEMBL5438543 | — | — | 1 | 6.30 |
| CHEMBL5414135 | — | — | 1 | 6.19 |
| CHEMBL5416960 | — | — | 1 | 6.09 |
| CHEMBL5436496 | — | — | 1 | 6.07 |
| CHEMBL5400673 | — | — | 1 | 6.00 |
| CHEMBL5439590 | — | — | 1 | 5.76 |
| CHEMBL1085742 | — | — | 1 | 5.40 |
| CHEMBL5400451 | — | — | 1 | - |
| CHEMBL5416348 | — | — | 1 | - |
| CHEMBL5405413 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5433689 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5429027 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5419663 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5407132 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5431826 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5418486 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5434111 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5399638 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL5416423 | — | IC50 | = | 53.7 | nM | 7.27 |
| CHEMBL5439307 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL5409254 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL5440967 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5401895 | — | EC50 | = | 159.0 | nM | 6.80 |
| CHEMBL5437820 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL5425931 | — | EC50 | = | 204.0 | nM | 6.69 |
| CHEMBL5435487 | — | EC50 | = | 293.0 | nM | 6.53 |
| CHEMBL5398234 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL5397470 | — | EC50 | = | 321.0 | nM | 6.49 |
| CHEMBL5397705 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL5438543 | — | EC50 | = | 495.0 | nM | 6.30 |
| CHEMBL5414135 | — | EC50 | = | 644.0 | nM | 6.19 |
| CHEMBL5416960 | — | EC50 | = | 807.0 | nM | 6.09 |
| CHEMBL5436496 | — | IC50 | = | 849.0 | nM | 6.07 |
| CHEMBL5400673 | — | IC50 | = | 1003.0 | nM | 6.00 |
| CHEMBL5439590 | — | EC50 | = | 1728.0 | nM | 5.76 |
| CHEMBL1085742 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5400451 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5416348 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5405413 | — | EC50 | > | 5000.0 | nM | - |