Assay Detail
Toxicity
CHEMBL5360237
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Inhibition of hERG by patch clamp assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.75 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5425931 | — | — | 1 | 5.22 |
| CHEMBL5413224 | — | — | 1 | 4.73 |
| CHEMBL5439307 | — | — | 1 | 4.52 |
| CHEMBL5433689 | — | — | 1 | 4.52 |
| CHEMBL5397470 | — | — | 1 | - |
| CHEMBL5405413 | — | — | 1 | - |
| CHEMBL5438543 | — | — | 1 | - |
| CHEMBL5416960 | — | — | 1 | - |
| CHEMBL5434111 | — | — | 1 | - |
| CHEMBL5397705 | — | — | 1 | - |
| CHEMBL5436496 | — | — | 1 | - |
| CHEMBL5400673 | — | — | 1 | - |
| CHEMBL5398234 | — | — | 1 | - |
| CHEMBL5419663 | — | — | 1 | - |
| CHEMBL5416423 | — | — | 1 | - |
| CHEMBL5416348 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5425931 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL5413224 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL5439307 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL5433689 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL5397470 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5405413 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5438543 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5416960 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5434111 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5397705 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5436496 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5400673 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5398234 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5419663 | — | IC50 | >= | 45000.0 | nM | - |
| CHEMBL5416423 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5416348 | — | IC50 | > | 50000.0 | nM | - |