Assay Detail

CHEMBL5360244

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Functional

Induction of TNF-alpha secretion in mouse whole blood

ChEMBL ↗

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Target

Blood (CHEMBL613561) ↗

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Primary target Blood

CHEMBL613561

Anchored from Assay target.

Protein identity Blood

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Mus musculus
Tissue	Blood
Confidence	1 — Organism
Curated By	Autocuration

Target

Blood (CHEMBL613561) ↗

Type	TISSUE
Organism	Mus musculus

Publication

Discovery of Novel TLR7 Agonists as Systemic Agent for Combination With aPD1 for Use in Immuno-oncology.

Poudel YB, He L, Cox M, Zhang Q, Johnson WL, Cong Q, Cheng H, Chowdari NS, Tarby C, Donnell AF, Broekema M, O'Malley DP, Zhang Y, A M Subbaiah M, Kumar BV, Subramani L, Wang B, Li YX, Sivaprakasam P, Critton D, Mulligan D, Sandhu B, Xie C, Ramakrishnan R, Nagar J, Dudhgaonkar S, Oderinde MS, Murtaza A, Schieven GL, Mathur A, Gavai AV, Vite G, Gangwar S.
ACS Med Chem Lett (2024) 15 : 181 -188
PubMed 38352830 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.47	8.47

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5419663	—	—	1	8.47

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5419663	—	EC50	=	3.4	nM	8.47