Assay Detail
Binding
CHEMBL5360423
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Agonist activity at human TLR7 in HEK-Blue hTLR7 cells harboring SEAP reporter transgene incubated for 18 hrs by quanti-blue reagent based assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-Blue hTLR7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 7.03 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5404211 | — | — | 1 | 7.92 |
| CHEMBL5419663 | — | — | 1 | 7.92 |
| CHEMBL5435264 | — | — | 1 | 7.89 |
| CHEMBL5417891 | — | — | 1 | 7.89 |
| CHEMBL5427289 | — | — | 1 | 7.85 |
| CHEMBL5426019 | — | — | 1 | 7.75 |
| CHEMBL5407698 | — | — | 1 | 7.68 |
| CHEMBL5414529 | — | — | 1 | 7.32 |
| CHEMBL5418809 | — | — | 1 | 7.31 |
| CHEMBL5403684 | — | — | 1 | 7.25 |
| CHEMBL5413224 | — | — | 1 | 7.24 |
| CHEMBL5411647 | — | — | 1 | 7.09 |
| CHEMBL5398842 | — | — | 1 | 7.08 |
| CHEMBL5427884 | — | — | 1 | 7.06 |
| CHEMBL5417342 | — | — | 1 | 6.88 |
| CHEMBL5427789 | — | — | 1 | 6.87 |
| CHEMBL5430110 | — | — | 1 | 6.84 |
| CHEMBL5419694 | — | — | 1 | 6.79 |
| CHEMBL5427518 | — | — | 1 | 6.57 |
| CHEMBL5400486 | — | — | 1 | 6.50 |
| CHEMBL5434082 | — | — | 1 | 6.43 |
| CHEMBL5413300 | — | — | 1 | 6.43 |
| CHEMBL5419165 | — | — | 1 | 6.34 |
| CHEMBL5424102 | — | — | 1 | 6.26 |
| CHEMBL5414156 | — | — | 1 | 6.24 |
| CHEMBL5427987 | — | — | 1 | 6.17 |
| CHEMBL5420635 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5404211 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5419663 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5435264 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5417891 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5427289 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5426019 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5407698 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5414529 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5418809 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL5403684 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5413224 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5411647 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5398842 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL5427884 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5417342 | — | EC50 | = | 133.0 | nM | 6.88 |
| CHEMBL5427789 | — | EC50 | = | 134.0 | nM | 6.87 |
| CHEMBL5430110 | — | EC50 | = | 145.0 | nM | 6.84 |
| CHEMBL5419694 | — | EC50 | = | 163.0 | nM | 6.79 |
| CHEMBL5427518 | — | EC50 | = | 272.0 | nM | 6.57 |
| CHEMBL5400486 | — | EC50 | = | 315.0 | nM | 6.50 |
| CHEMBL5434082 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5413300 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5419165 | — | EC50 | = | 461.0 | nM | 6.34 |
| CHEMBL5424102 | — | EC50 | = | 549.0 | nM | 6.26 |
| CHEMBL5414156 | — | EC50 | = | 572.0 | nM | 6.24 |
| CHEMBL5427987 | — | EC50 | = | 668.0 | nM | 6.17 |
| CHEMBL5420635 | — | EC50 | = | 780.0 | nM | 6.11 |