Assay Detail
Toxicity
CHEMBL5360427
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG
26
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.71 | 5.40 |
| Inhibition | 5 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5417891 | — | — | 1 | 5.40 |
| CHEMBL5427987 | — | — | 1 | 5.00 |
| CHEMBL5407698 | — | — | 1 | 4.89 |
| CHEMBL5417342 | — | — | 1 | 4.85 |
| CHEMBL5398842 | — | — | 1 | 4.72 |
| CHEMBL5413224 | — | — | 1 | 4.62 |
| CHEMBL5430110 | — | — | 1 | 4.52 |
| CHEMBL5400486 | — | — | 1 | 4.49 |
| CHEMBL5427289 | — | — | 1 | 4.37 |
| CHEMBL5411647 | — | — | 1 | 4.21 |
| CHEMBL5420635 | — | — | 1 | - |
| CHEMBL5427884 | — | — | 1 | - |
| CHEMBL5424102 | — | — | 1 | - |
| CHEMBL5414156 | — | — | 1 | - |
| CHEMBL5419165 | — | — | 1 | - |
| CHEMBL5419694 | — | — | 1 | - |
| CHEMBL5426019 | — | — | 1 | - |
| CHEMBL5418809 | — | — | 1 | - |
| CHEMBL5427518 | — | — | 1 | - |
| CHEMBL5403684 | — | — | 1 | - |
| CHEMBL5413300 | — | — | 1 | - |
| CHEMBL5434082 | — | — | 1 | - |
| CHEMBL5414529 | — | — | 1 | - |
| CHEMBL5404211 | — | — | 1 | - |
| CHEMBL5427789 | — | — | 1 | - |
| CHEMBL5435264 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5417891 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5427987 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5407698 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5417342 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5398842 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL5413224 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5430110 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL5400486 | — | IC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL5427289 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL5411647 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL5420635 | — | Inhibition | - | % | - | |
| CHEMBL5427884 | — | Inhibition | - | % | - | |
| CHEMBL5424102 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5414156 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5419165 | — | Inhibition | - | % | - | |
| CHEMBL5419694 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5426019 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5418809 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5427518 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5403684 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5413300 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5434082 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5414529 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5404211 | — | Inhibition | - | % | - | |
| CHEMBL5427789 | — | Inhibition | - | % | - | |
| CHEMBL5435264 | — | IC50 | > | 50000.0 | nM | - |