Assay Detail
Functional
CHEMBL5360448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human 5-HT2C receptor expressed in CHO cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay
31
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Evaluation of the Indazole Analogs of 5-MeO-DMT and Related Tryptamines as Serotonin Receptor 2 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 6.88 | 7.58 |
| pEC50 | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406172 | — | — | 2 | 7.58 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 2 | 7.51 |
| CHEMBL5404610 | — | — | 2 | 7.42 |
| CHEMBL5424175 | — | — | 2 | 7.24 |
| CHEMBL5425772 | — | — | 2 | 6.94 |
| CHEMBL5439312 | — | — | 2 | 6.62 |
| CHEMBL5434434 | — | — | 2 | 6.58 |
| CHEMBL5405688 | — | — | 2 | 6.41 |
| CHEMBL5437030 | — | — | 2 | 6.24 |
| CHEMBL5399968 | — | — | 1 | 5.69 |
| CHEMBL5438716 | — | — | 2 | - |
| CHEMBL5429252 | — | — | 2 | - |
| CHEMBL5429912 | — | — | 2 | - |
| CHEMBL5394562 | — | — | 2 | - |
| CHEMBL5422659 | — | — | 2 | - |
| CHEMBL5401685 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406172 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL5406172 | — | EC50 | = | 26.3 | nM | 7.58 |
| CHEMBL7257 | MEBUFOTENIN | EC50 | = | 30.7 | nM | 7.51 |
| CHEMBL7257 | MEBUFOTENIN | EC50 | = | 36.31 | nM | 7.44 |
| CHEMBL5404610 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL5404610 | — | EC50 | = | 38.9 | nM | 7.41 |
| CHEMBL5424175 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5424175 | — | EC50 | = | 58.88 | nM | 7.23 |
| CHEMBL5425772 | — | EC50 | = | 114.82 | nM | 6.94 |
| CHEMBL5425772 | — | EC50 | = | 115.0 | nM | 6.94 |
| CHEMBL5439312 | — | EC50 | = | 239.88 | nM | 6.62 |
| CHEMBL5439312 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5434434 | — | EC50 | = | 264.0 | nM | 6.58 |
| CHEMBL5434434 | — | EC50 | = | 263.03 | nM | 6.58 |
| CHEMBL5405688 | — | EC50 | = | 394.0 | nM | 6.41 |
| CHEMBL5405688 | — | EC50 | = | 389.05 | nM | 6.41 |
| CHEMBL5437030 | — | EC50 | = | 575.44 | nM | 6.24 |
| CHEMBL5437030 | — | EC50 | = | 576.0 | nM | 6.24 |
| CHEMBL5399968 | — | EC50 | = | 2061.0 | nM | 5.69 |
| CHEMBL5394562 | — | pEC50 | - | — | - | |
| CHEMBL5422659 | — | pEC50 | - | — | - | |
| CHEMBL5401685 | — | pEC50 | - | — | - | |
| CHEMBL5429912 | — | pEC50 | - | — | - | |
| CHEMBL5429252 | — | pEC50 | - | — | - | |
| CHEMBL5438716 | — | pEC50 | - | — | - | |
| CHEMBL5401685 | — | EC50 | - | — | - | |
| CHEMBL5422659 | — | EC50 | - | — | - | |
| CHEMBL5394562 | — | EC50 | - | — | - | |
| CHEMBL5429912 | — | EC50 | - | — | - | |
| CHEMBL5429252 | — | EC50 | - | — | - | |
| CHEMBL5438716 | — | EC50 | - | — | - |