Assay Detail
Binding
CHEMBL5360734
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of eNOS in human DLD-1 cells assessed as reduction of L-[14C]arginine to L-[14C]citrulline conversion
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical similarities and differences among inhibitors of nitric oxide synthase, arginase and dimethylarginine dimethylaminohydrolase-1: Implications for the design of novel enzyme inhibitors modulating the nitric oxide pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.91 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483091 | — | — | 1 | 7.66 |
| CHEMBL321691 | ETHYLISOTHIOUREA | — | 1 | 7.41 |
| CHEMBL483092 | — | — | 1 | 6.17 |
| CHEMBL107201 | — | — | 1 | 5.05 |
| CHEMBL505665 | BENZYL CARBAMIMIDOTHIOATE | — | 1 | 4.64 |
| CHEMBL301607 | — | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483091 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL321691 | ETHYLISOTHIOUREA | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL483092 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL107201 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL505665 | BENZYL CARBAMIMIDOTHIOATE | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL301607 | — | Ki | = | 31000.0 | nM | 4.51 |