Assay Detail
Binding
CHEMBL5360872
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Inhibition of CDK9 (unknown origin) incubated for 10 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ligand- and structure-based identification of novel CDK9 inhibitors for the potential treatment of leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.83 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 8.35 |
| CHEMBL1568996 | — | — | 1 | 6.67 |
| CHEMBL5413586 | — | — | 1 | 6.66 |
| CHEMBL5404071 | — | — | 1 | 6.53 |
| CHEMBL1387710 | — | — | 1 | 6.47 |
| CHEMBL5425180 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1568996 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL5413586 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL5404071 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL1387710 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL5425180 | — | IC50 | = | 504.0 | nM | 6.30 |