Assay Detail
Functional
CHEMBL5360968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at KOR (unknown origin) by measuring cAMP inhibition
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.71 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440765 | U-69593 | — | 1 | 9.49 |
| CHEMBL1186579 | METHYLNALTREXONE | 4.0 | 1 | 8.17 |
| CHEMBL100116 | PENTAZOCINE | 4.0 | 1 | 7.40 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 7.40 |
| CHEMBL5406584 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440765 | U-69593 | EC50 | = | 0.32 | nM | 9.49 |
| CHEMBL1186579 | METHYLNALTREXONE | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL100116 | PENTAZOCINE | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL60542 | (+)-PENTAZOCINE | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5406584 | — | EC50 | = | 853.0 | nM | 6.07 |