Assay Detail
Functional
CHEMBL5360977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human KOR expressed in CHO cell membranes by beta-arrestin translocation assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A systematic review on the kappa opioid receptor and its ligands: New directions for the treatment of pain, anxiety, depression, and drug abuse.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.19 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118865 | SPIRADOLINE | 2.0 | 1 | 9.00 |
| CHEMBL4458783 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118865 | SPIRADOLINE | EC50 | = | 1.01 | nM | 9.00 |
| CHEMBL4458783 | — | EC50 | = | 4129.0 | nM | 5.38 |