Assay Detail
Functional
CHEMBL5361076
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human HT-29 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure activity relationship (SAR) and anticancer activity of pyrrolidine derivatives: Recent developments and future prospects (A review).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.76 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5395074 | — | — | 1 | 6.41 |
| CHEMBL5416877 | — | — | 1 | 6.41 |
| CHEMBL5395035 | — | — | 1 | 6.41 |
| CHEMBL5414752 | — | — | 1 | 6.04 |
| CHEMBL1275863 | — | — | 1 | 5.99 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 4.70 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5395074 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5416877 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5395035 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5414752 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL1275863 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 19940.0 | nM | 4.70 |
| CHEMBL595 | PIOGLITAZONE | IC50 | = | 40300.0 | nM | 4.39 |