Assay Detail
Functional
CHEMBL5361083
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Anticancer activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure activity relationship (SAR) and anticancer activity of pyrrolidine derivatives: Recent developments and future prospects (A review).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.73 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 6.54 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.46 |
| CHEMBL5416877 | — | — | 1 | 6.41 |
| CHEMBL5395035 | — | — | 1 | 6.41 |
| CHEMBL5414752 | — | — | 1 | 4.33 |
| CHEMBL5395074 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595 | PIOGLITAZONE | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5416877 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5395035 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5414752 | — | IC50 | = | 47250.0 | nM | 4.33 |
| CHEMBL5395074 | — | IC50 | = | 61920.0 | nM | 4.21 |